Clinical application of beryllium lymphocyte proliferation testing.
نویسندگان
چکیده
Because of its unique properties, beryllium has become widely used in a variety of industrial applications, including inertial guidance systems, turbine rotor blades, laser tubes, rocket engine liners, springs, aircraft brakes and landing gear, ball bearings, injection and blow mold tooling, electrical contacts, automotive electronics, X-ray tube windows, spark plugs, electrical components, ceramic applications, gears, aircraft engines, oil and gas industries, welding electrodes, computer electronics, and golf clubs. It is extremely light, with a high modulus of elasticity (stiffness), a low coefficient of thermal expansion, high thermal and electrical conductivities, and a high melting point. Pure beryllium metal is useful in the nuclear industry as a moderator to slow neutrons, increasing the effectiveness of fission. More frequently, it is formulated as an alloy or an oxide.
منابع مشابه
Use of beryllium lymphocyte proliferation testing for screening of asymptomatic individuals: an evidence-based assessment.
OBJECTIVE We reviewed published data describing use of beryllium lymphocyte proliferation testing (BeLPT) to determine the appropriateness of BeLPT for screening asymptomatic individuals. METHODS Published studies were identified by computerized literature searches and hand searches of relevant bibliographies and cited references. Critical assessment of evidence focused on five elements essen...
متن کاملSignificance of the blood beryllium lymphocyte proliferation test.
The blood beryllium lymphocyte proliferation test (BeLPT) is an in vitro measure of the beryllium antigen-specific cell-mediated immune response. This response to beryllium is now understood to play a central role in the immunopathogenesis of chronic beryllium disease (CBD). Although there remain some unresolved methodologic issues with testing, the blood BeLPT has already undergone sufficient ...
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Screening for disease-associated genetic markers may provide new tools for prevention of occupational diseases (22). So far in CBD, blood and lung lymphocyte testing for Be-specific proliferation have been used to identify individuals with Be allergy and disease (23). However, because lymphocyte tests do not predict disease or risk, genetic testing may have a role, in association with lymphocyt...
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The potential hazards from exposure to beryllium or beryllium compounds in the workplace were first reported in the 1930s. The tritiated thymidine beryllium lymphocyte proliferation test (BeLPT) is an in vitro blood test that is widely used to screen beryllium exposed workers in the nuclear industry for sensitivity to beryllium. Newman [18] has discussed the clinical significance of the BeLPT a...
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ورودعنوان ژورنال:
- Clinical and diagnostic laboratory immunology
دوره 10 6 شماره
صفحات -
تاریخ انتشار 2003